Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features | Zendy

Jôice Dias Corrêa | Zendy; Celso Martins QueirozJunior | Zendy; José Eustáquio Costa | Zendy; Antônio Lúcio Teixeira | Zendy; Tarcı́lia Aparecida Silva | Zendy

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Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features

Author(s) -

Jôice Dias Corrêa,

Celso Martins QueirozJunior,

José Eustáquio Costa,

Antônio Lúcio Teixeira,

Tarcı́lia Aparecida Silva

Publication year - 2011

Publication title -

isrn dentistry

Language(s) - English

Resource type - Journals

eISSN - 2090-438X

pISSN - 2090-4371

DOI - 10.5402/2011/497850

Subject(s) - phenytoin , immune system , extracellular matrix , inflammation , pathogenesis , connective tissue , medicine , drug , calcium channel , pharmacology , immunology , calcium , chemistry , pathology , epilepsy , biochemistry , psychiatry

Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, with varying degrees of inflammation. One of the main drugs associated with GO is the antiepileptic phenytoin, which affects gingival tissues by altering extracellular matrix metabolism. Nevertheless, the pathogenesis of such drug-induced GO remains fulfilled by some contradictory findings. This paper aims to present the most relevant studies regarding the molecular, immune, and inflammatory aspects of phenytoin-induced gingival overgrowth.

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