Genetic Effects of Trabecular Titanium on MG-63 Cell Line: A Genetic Profiling Evaluation | Zendy

Sollazzo Vincenzo | Zendy; Leo Massari | Zendy; Furio Pezzetti | Zendy; Ambra Girardi | Zendy; Francesca Farinella | Zendy; Vincenzo Lorusso | Zendy; Silvia Burelli | Zendy; Bloch Hans Rudolf | Zendy; Francesco Carinci | Zendy

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Genetic Effects of Trabecular Titanium on MG-63 Cell Line: A Genetic Profiling Evaluation

Author(s) -

Sollazzo Vincenzo,

Leo Massari,

Furio Pezzetti,

Ambra Girardi,

Francesca Farinella,

Vincenzo Lorusso,

Silvia Burelli,

Bloch Hans Rudolf,

Francesco Carinci

Publication year - 2011

Publication title -

isrn materials science

Language(s) - English

Resource type - Journals

eISSN - 2090-6099

pISSN - 2090-6080

DOI - 10.5402/2011/392763

Subject(s) - titanium , osseointegration , dna microarray , osteoblast , biocompatibility , biomaterial , gene expression profiling , microarray , gene expression , materials science , gene , biomedical engineering , microbiology and biotechnology , in vitro , biology , nanotechnology , implant , biochemistry , medicine , metallurgy , surgery

Pure titanium and titanium alloys are materials widely used in orthopaedics because of their mechanical properties, chemical stability, and biocompatibility. Recently, a new highly porous titanium biomaterial named Trabecular Titanium (TT) has been developed. In this in vitro study, we tested the genetic effects of TT on osteoblast-like cells (MG63) using DNA microarrays technology: cDNA microarrays provides the ability to comparatively analyze mRNA expression of thousands of genes in parallel thus showing activated and repressed genes by the presence of the TT. Several genes that were significantly up- or downregulated have been identified. Globally, it was demonstrated that TT stimulates osteoblasts proliferation and differentiation, and reduces apoptosis. Therefore, all these effects can contribute to improve the osseointegration of this material. These results encourage the clinical application of Trabecular Titanium to prosthetic devices.

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