Giant Retroperitoneal Mucinous Tumor Supportively Diagnosed as a Dedifferentiated Liposarcoma by Fluorescence In Situ Hybridization of MDM2 Gene | Zendy

Taku Naiki | Zendy; Shuzo Hamamoto | Zendy; Noriyasu Kawai | Zendy; Aya NaikiIto | Zendy; Yoshiyuki Kojima | Zendy; Takahiro Yasui | Zendy; Keiichi Tozawa | Zendy; Kenjiro Kohri | Zendy

Open Access

Giant Retroperitoneal Mucinous Tumor Supportively Diagnosed as a Dedifferentiated Liposarcoma by Fluorescence In Situ Hybridization of MDM2 Gene

Author(s) -

Taku Naiki,

Shuzo Hamamoto,

Noriyasu Kawai,

Aya NaikiIto,

Yoshiyuki Kojima,

Takahiro Yasui,

Keiichi Tozawa,

Kenjiro Kohri

Publication year - 2011

Publication title -

isrn urology

Language(s) - English

Resource type - Journals

eISSN - 2090-5815

pISSN - 2090-5807

DOI - 10.5402/2011/261735

Subject(s) - fluorescence in situ hybridization , liposarcoma , pathology , in situ hybridization , immunohistochemistry , mdm2 , fish <actinopterygii> , medicine , in situ , biology , sarcoma , gene , gene expression , chemistry , biochemistry , fishery , chromosome , organic chemistry

Surgical resection was performed on a 47-year-old woman for a retroperitoneal mass that weighed 8.5 kg. Histological examination revealed a myxoid sarcomatous tumor. Because diagnosis could not be determined by immunohistochemistry, attention was focused on MDM2 (murine double minute) gene amplification by fluorescence in situ hybridization (FISH) analysis. The tumor was finally determined to be a dedifferentiated liposarcoma. We experienced a case of a giant retroperitoneal dedifferentiated liposarcoma. FISH analysis was useful for the diagnosis and determination of the therapeutic strategy.

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