Evaluation of the In Situ Hybridization Signal Patterns of Liquid-Based Cytological Human Papillomavirus Specimens for Diagnosing Squamous Intraepithelial Lesion | Zendy

Katsunari Ishida | Zendy; Makoto Nagasaki | Zendy; Masayuki Kobayashi | Zendy; Tatsushi Nakagawa | Zendy; Toru Nabika | Zendy; Kiyomi Taniyama | Zendy

Open Access

Evaluation of the In Situ Hybridization Signal Patterns of Liquid-Based Cytological Human Papillomavirus Specimens for Diagnosing Squamous Intraepithelial Lesion

Author(s) -

Katsunari Ishida,

Makoto Nagasaki,

Masayuki Kobayashi,

Tatsushi Nakagawa,

Toru Nabika,

Kiyomi Taniyama

Publication year - 2011

Publication title -

isrn pathology

Language(s) - English

Resource type - Journals

eISSN - 2090-570X

pISSN - 2090-5718

DOI - 10.5402/2011/219790

Subject(s) - algorithm , computer science

To examine the diagnostic utility for squamous intraepithelial lesion (SIL) by cytological in situ hybridization (c-ISH) for the human papillomavirus using liquid-based cytology specimens, we investigated c-ISH signal patterns in the cases of low-grade SIL (LSIL), atypical squamous cells of undetermined significance (ASC-US), and high-grade SIL (HSIL). Episomal (E) and/or integrated (I) signals were observed. Two signal patterns (≧ or >) were obtained by counting the number of

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