Acalculous Cholecystitis in a Patient with Hepatocellular Carcinoma on Sorafenib | Zendy

Mariko Sanda | Zendy; Hideyuki Tamai | Zendy; Hisanobu Deguchi | Zendy; Yoshiyuki Mori | Zendy; Kosaku Moribata | Zendy; Naoki Shingaki | Zendy; Kazuki Ueda | Zendy; Izumi Inoue | Zendy; Takao Maekita | Zendy; Mikitaka Iguchi | Zendy; Kimihiko Yanaoka | Zendy; Masashi Oka | Zendy; Masao Ichinose | Zendy

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Acalculous Cholecystitis in a Patient with Hepatocellular Carcinoma on Sorafenib

Author(s) -

Mariko Sanda,

Hideyuki Tamai,

Hisanobu Deguchi,

Yoshiyuki Mori,

Kosaku Moribata,

Naoki Shingaki,

Kazuki Ueda,

Izumi Inoue,

Takao Maekita,

Mikitaka Iguchi,

Kimihiko Yanaoka,

Masashi Oka,

Masao Ichinose

Publication year - 2010

Publication title -

isrn gastroenterology

Language(s) - English

Resource type - Journals

eISSN - 2090-4401

pISSN - 2090-4398

DOI - 10.5402/2011/201529

Subject(s) - medicine , hepatocellular carcinoma , sorafenib , gallbladder , cholecystitis , cirrhosis , carcinoma , cholecystectomy , radiology , gastroenterology

A 67-year-old woman with compensated cirrhosis type B associated with hepatocellular carcinoma was started on sorafenib for multiple pulmonary metastases. The patient developed right upper quadrant pain and high fever 4 weeks later. Imaging revealed marked enlargement of the gallbladder without calculi. Following percutaneous transhepatic gallbladder aspiration, her symptoms resolved, but the gallbladder remained enlarged. Laparoscopic cholecystectomy was performed. Arteriolar occlusion with intimal thickening in the muscular layer of the gallbladder was seen sporadically. The fact that this patient had no risk factors for acalculous cholecystitis suggested that the cholecystitis resulted from ischemia, implying a strong causal relationship with sorafenib.

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