EMPREGO DA COLA N-BUTIL CIANOACRILATO NA FIXAÇÃO DE RETALHO CUTÂNEO EM RATOS

O proposito do presente estudo foi avaliar clinica e histopatologicamente o uso da cola de n-butil cianoacrilato em procedimentos de retalho de avanco, uma vez que a mesma e frequentemente utilizada em feridas pequenas com baixa tensao de pele. Foram utilizados 18 ratos, linhagem Wistar, divididos em dois grupos de nove. Apos produzir-se uma ferida cutânea retangular de 2,0 x 1,5 cm, incluindo o musculo tronco cutâneo, na regiao toracica dorso-lateral esquerda, a mesma foi restaurada por meio de retalho cutâneo de pediculo unico. No grupo I, o retalho foi fixado aplicando-se cola de n-butil cianoacrilato aplicada apenas na superficie interna das bordas e no grupo II realizaram-se pontos isolados com fio de nailon 4-0. Para avaliacao histologica, tres animais de cada grupo foram submetidos a eutanasia aos 07, 15 e 30 dias de pos-operatorio.O tempo cirurgico foi menor no grupo I, sendo a cola de facil aplicacao. Em ambos grupos observaram-se complicacoes, como inflamacao e deiscencia, porem sem diferencas estatisticas. O padrao cicatricial foi semelhante nos dois grupos. Foi possivel concluir que a cola de n-butil cianoacrilato comportouse de forma semelhante a sutura, na sintese de retalhos cutâneos de pediculo unico em ratos. Use of n-butyl cyanoacrylate glue with single pedicle advancement flap in rats Abstract The aim of this study was to evaluate clinically and histopathologically the use of nbutyl cyanoacrylate glue in advancement flap procedures, because this glue is usually used in small wounds with low skin tension. Eighteen Wistar rats with weight between 300 and 400 g were used and divided in two groups of nine each. A 2.0 x 1.5 cm rectangular skin wound, including the cutaneous trunci muscle, was performed in the left dorsal lateral thoracic side and repaired using the single pedicle advancement flap technique. In the first group, the flap was fixed with the glue on the internal surface of the edges. In the second group, the flap was fixed with simple interrupted suture using nylon 4-0. The surgical time was lower in group I, and glue application was easy. In both groups were observed complications, such as inflammation and wound dehiscence, but there was no statistical difference. Three animals from each group were euthanatized at seven, 15 and 30 days postoperative to realize the histological examination. It was possible to conclude that, macroscopically and microscopically, n-butyl cyanoacrylate glue was similar to suture in fixation of single pedicle advancement flap in rats.