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O objetivo do presente trabalho foi o de testar em modelo experimental de glaucoma e em olhos sadios de gatos, duas tecnicas cirurgicas filtrantes associadas ao uso topico no pos-operatorio de Acido Salicilico (AS). Este ultimo e reconhecidamente um excelente antiprostaglandinico, alem de ter acao queratolitica, podendo facilitar a patencia da cirurgia filtrante. Inicialmente foi realizado um teste de toxicidade ocular do colirio de AS a 0,3%, em tres gatos (tres olhos). Na sequencia, estes animais foram submetidos a injecoes de uma solucao supersaturada de carbono na câmara anterior, resultando em glaucomas com pressao intra-ocular de 40 mmHg em apenas 48 horas. Em seguida foram realizadas as cirurgias filtrantes no grupo com glaucoma e em outro grupo de tres, sem pressao intra-ocular elevada. No periodo pos-operatorio, cinco gatos receberam instilacoes do colirio de AS, tres vezes ao dia durante 7 dias e, uma vez ao dia ate o 25 dia, e um gato permaneceu como controle. Este ultimo, teve recidiva do glaucoma no setimo dia do posoperatorio. Os cinco gatos que receberam a colirio de AS foram observados, quanto a patencia da bolha de filtracao, ate o 25o dia, quando se observou em todos os animais filtracao adequada. Conclui-se que o colirio de acido salisilico possui uma boa acao antifibrotica e antiinflamatoria, permitindo a patencia de filtracao no pos-operatorio. Deep sclerectomy with periferic iridectomy associated to the topical use of salicilic acid in experimental glaucoma in cats Abstract The main aim of the present research work is the testing of two techniques of filtrating surgery in order to get an experimental model of glaucoma in healthy cat eyes. This technique was associated with the topical use of 0.3% solution of salicilic acid (SA) due to its antiprostaglandin and antifibrotic properties, maintaining, this way, the filtrating surgery. Firstly, the three experimental cats underwent a toxic tolerance test. The glaucoma model was obtained by the injection of a supersaturated solution of carbon fiber in the eye anterior chamber. After a period of 48 hours, all the three animals developed a glaucoma displaying intraocular pressure above 40 mmHg. This group and another group of three cats with normal intraocular pressure were submitted to the same surgical and medical protocols. Five of this animals were medicated with topical drops of SA, the remainder one, used as control, developed glaucoma around the seventh day after the operation. The salicilic acid treated cats were observed for the maintenance of the filtrating bubble during 25 days, all of them displaying good aqueous filtration, an observations that allowed the conclusion that salicilic acid displays a marked antifibrotic and antiinflamatory activity towards the sclera, allowing the efficacy of the filtrating surgery.

ESCLERECTOMIA PROFUNDA COM IRIDECTOMIA PERIFÉRICA ASSOCIADA AO USO TÓPICO DE ÁCIDO SALICÍLICO EM GLAUCOMA EXPERIMENTAL EM GATOS