AVALIAÇÃO DE DIVERSAS FORMULAÇÕES DE XAMPUS DE CETOCONAZOL QUANTO AO EMPREGO DE DIFERENTES ANTIOXIDANTES E SOLUBILIZANTES

Shampoos are products for cleaning or fixing substances in hair or scalp. Especially in the treatment products, the cleaning action can be accompanied by a pharmacological stimulant or normalizing physiological functions of the hair bulb and sebaceous glands. The most common scalp or hair’s skin problems are dandruff and seborrhea. Most commercially available treatments on the market for these two skin disorders has antifungal agents such as zinc pyrithione, selenium sulfide, ciclopirox olamine and, in particular, ketoconazole, made widely prescribed and manipulated in magistral pharmacies who knowingly can modify the stability of shampoos. Ketoconazole formulations change the product’s color to which it is added. For this reason, the use of an antioxidant agent becomes indispensable. In this context, the objective of this study was to evaluate different formulations of ketoconazole shampoo 2% as its visual appearance, pH and viscosity after the use of different antioxidants and solubilizers. Of the formulations tested, those that used the dipropylene glycol and