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Oral mucosal desquamation (OMD) is an irritative reaction caused by products containing sodium lauryl sulfate (SLS), an anionic detergent that causes a stronger denaturation effect in intercellular structure epithelium. Case Series: Describing four cases of OMD induced by dentifrices, as an endeavor to make the condition better known, improving its diagnosis by clinicians based on minimal intervention. Conclusion: Oral mucosal desquamation should be considered as a differential diagnosis of the desquamative lesions of the mouth. Clinical signs and symptomatology should disappear in one week after discontinuation potentially involved products.

Could sodium lauryl sulfate be an irritant factor in oral mucosal desquamation?