Can IgA, C3, IL-6 and TNF-α act as predictors for reoccurrence of breast cancer among Iraqi women? | Zendy

Nadham Kadham Mahdi | Zendy; Mohammad Hussein Al-Jowher | Zendy; Hiba Ali | Zendy

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Can IgA, C3, IL-6 and TNF-α act as predictors for reoccurrence of breast cancer among Iraqi women?

Author(s) -

Nadham Kadham Mahdi,

Mohammad Hussein Al-Jowher,

Hiba Ali

Publication year - 2013

Publication title -

qatar medical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.171

H-Index - 9

eISSN - 2227-0426

pISSN - 0253-8253

DOI - 10.5339/qmj.2013.6

Subject(s) - medicine , chemotherapy , breast cancer , tumor necrosis factor alpha , cancer , immunology , gastroenterology

Blood samples were collected from 30 women with age ranged from 27-70 years after 3 cycles of chemotherapy. Sera were used for IgA, IgG, IgM, C3, C4, IL-6 and TNF-α estimation. After 3 cycles of chemotherapy, all the immunological parameters reduced except TNF-α. Patients who developed disease reoccurrence after chemotherapy exhibit a significantly higher IgA, C3, IL-6 and TNF-α levels after 3 cycles of chemotherapy than patients who did not (p < 0.05). Therefore, serum IgA, C3, IL-6 and TNF-α can be used as predictors for breast cancer reoccurrence.

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