Is there a role for genetic risk assessment in the treatment of dyslipidemia in primary and secondary prevention of coronary heart disease? | Zendy

Jassim Al Suwaidi | Zendy

Open Access

Is there a role for genetic risk assessment in the treatment of dyslipidemia in primary and secondary prevention of coronary heart disease?

Author(s) -

Jassim Al Suwaidi

Publication year - 2015

Publication title -

global cardiology science and practice

Language(s) - English

Resource type - Journals

ISSN - 2305-7823

DOI - 10.5339/gcsp.2015.19

Subject(s) - dyslipidemia , medicine , secondary prevention , primary prevention , coronary heart disease , randomized controlled trial , disease , statin , genetic variants , cardiology , genotype , genetics , gene , biology

Genetic variants have been associated with the risk of coronary heart disease (CHD). Mega et al studied the association of a genetic risk score based on 27 genetic variants with incidents of recurrent CHD, adjusting for traditional risk factors using data from a community based study and 4 randomized controlled trials of both primary and secondary prevention with statin therapy. When individuals were divided into low, intermediate and high genetic risk categories, a significant gradient in risk of incident and recurrent CHD was shown.

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