Solvent-free synthesis, spectral studies, antimicrobial activities of some (E)-N-(substituted benzylidene)-9-ethyl-9H-carbazole-3-amine derivatives

Background: This study aims to synthesis a series of (E)-N-(substituted benzylidene)-9-ethyl-9H-carbazole-3-amines, using solvent-free fly-ash:perchloric acid catalyst under microwave irradiation. To then characterize them using analytical, physical and spectroscopic data. Methods: Solvent-free microwave assisted (E)imines were adopted for the synthesis of (E)-N-(substituted benzylidene)-9-ethyl-9H-carbazole-3-amine, using fly-ash:perchloric acid as a catalyst. They were characterized by IR, NMR and mass spectroscopic data. The IR and NMR spectral data was correlated with substituent constants, F and R parameters using Hammett equation to study the effect of the substituents. Results: The yield of the synthesized imines were more than 75%. The spectral data of these (E)-N-(substituted benzylidene)-9-ethyl-9H-carbazole-3-amines had been correlated using single and multi-regression analysis. These gave a satisfactory or fair degree of correlation, with some parameters. Conclusion: Easy handling, non-hazardo...