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Bisphosphonates are antiresorptive acting specifically on the activity of osteoclasts. A serious complication of their use is osteonecrosis of the jaw, defined as an area of exposed bone in the maxillofacial area without resolve spontaneously over a period of at least 8 weeks in patients with history of use of bisphosphonate compounds, but which have not been subjected to radiotherapy in the head and neck. Conservative treatments are recommended, but the literature results are controversial and not always effective. So new approaches such as the use of platelet concentrates, have been suggested. Swill autologous products containing high concentrations of growth factors that act as cell adhesion molecules, accelerating bone repair. Objective: describe, through case report the use of fibrin rich plasma and leukocyte (L-PRF) as treatment of jaw osteonecrosis. Case report: female patient, 79, diagnosed with jaw osteonecrosis associated with bisphosphonate use, treated by conventional surgery involving bone curettage and flap rotation, but without success. Surgical

Osteonecrose mandibular associada ao uso de bisfosfonatos tratada com plasma rico em fibrina leucocitária: relato de caso