Dissociative Tremor Response with Pallidal Deep Brain Stimulation in Parkinson’s Disease | Zendy

Anson Wang | Zendy; Eric Molho | Zendy; Yingmai Yang | Zendy; Julie G. Pilitsis | Zendy; Adolfo RamirezZamora | Zendy

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Dissociative Tremor Response with Pallidal Deep Brain Stimulation in Parkinson’s Disease

Author(s) -

Anson Wang,

Eric Molho,

Yingmai Yang,

Julie G. Pilitsis,

Adolfo RamirezZamora

Publication year - 2020

Publication title -

tremor and other hyperkinetic movements

Language(s) - English

Resource type - Journals

ISSN - 2160-8288

DOI - 10.5334/tohm.568

Subject(s) - deep brain stimulation , stimulation , neuroscience , subthalamic nucleus , neuromodulation , parkinson's disease , psychology , resting tremor , thalamic stimulator , dissociative , physical medicine and rehabilitation , medicine , disease , psychiatry

Background: Pallidal and subthalamic targets are commonly used for deep brain stimulation in Parkinson’s disease (PD), with similar efficacy for resting tremor control. However, neuromodulatory effects on kinetic and postural tremor in PD is less clear. Case Report: We present a 67-year-old PD patient with marked dissociative tremor response following pallidal neuromodulation. We observed excellent resting tremor suppression, but postural and kinetic tremors remained severe, requiring additional thalamic VIM stimulation for management. Discussion: Our findings illustrate the phenotypical differences in PD and differential response to diverse tremor characteristics with distinctive stimulation targets. Additional studies are necessary to understand these differences.

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