Imaging Features of Hypertrophic Olivary Degeneration | Zendy

Ruth Van Eetvelde | Zendy; Marc Lemmerling | Zendy; T. Backaert | Zendy; N. Favoreel | Zendy; Bert Geerts | Zendy; C. Sommeling | Zendy; Dimitri Hemelsoet | Zendy; Sven Dekeyzer | Zendy

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Imaging Features of Hypertrophic Olivary Degeneration

Author(s) -

Ruth Van Eetvelde,

Marc Lemmerling,

T. Backaert,

N. Favoreel,

Bert Geerts,

C. Sommeling,

Dimitri Hemelsoet,

Sven Dekeyzer

Publication year - 2016

Publication title -

journal of the belgian society of radiology

Language(s) - English

Resource type - Journals

ISSN - 1780-2393

DOI - 10.5334/jbr-btr.1065

Subject(s) - inferior olivary nucleus , dentate nucleus , red nucleus , medicine , cerebellum , degeneration (medical) , myoclonus , cerebellar degeneration , anatomy , neuroscience , hyperintensity , magnetic resonance imaging , nucleus , pathology , psychology , radiology

Hypertrophic olivary degeneration (HOD) is a unique form of transneuronal degeneration caused by a disruption of the dentato-rubro-olivary pathway, also known as the triangle of Guillain-Mollaret. The triangle of Guillain-Mollaret is involved in fine voluntary motor control and consists of both the inferior olivary nucleus and the red nucleus on one side and the contralateral dentate nucleus. Clinically, patients classically present with symptomatic palatal myoclonus. Typical magnetic resonance imaging findings include T2-hyperintensity and enlargement of the inferior olivary nucleus evolving over time to atrophy with residual T2-hyperintensity. In this article, we provide a case-based illustration of the anatomy of the Guillain-Mollaret-triangle and the typical imaging findings of hypertrophic olivary degeneration.

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