Effect of Freeze-Drying on the Mechanical, Physical and Morphological Properties of Glutaraldehyde-Treated Bovine Pericardium: Evaluation of Freeze-Dried Treated Bovine Pericardium Properties | Zendy

Camila Figueiredo Borgogi | Zendy; Marina J.S. Maizato | Zendy; Adolfo A. Leirner | Zendy; Bronislaw Polakiewicz | Zendy; Marisa Masumi Beppu | Zendy; Olga Z. Higa | Zendy; Ronaldo N.M. Pitombo | Zendy

Open Access

Effect of Freeze-Drying on the Mechanical, Physical and Morphological Properties of Glutaraldehyde-Treated Bovine Pericardium: Evaluation of Freeze-Dried Treated Bovine Pericardium Properties

Author(s) -

Camila Figueiredo Borgogi,

Marina J.S. Maizato,

Adolfo A. Leirner,

Bronislaw Polakiewicz,

Marisa Masumi Beppu,

Olga Z. Higa,

Ronaldo N.M. Pitombo

Publication year - 2010

Publication title -

journal of applied biomaterials and functional materials

Language(s) - English

Resource type - Journals

eISSN - 1724-6024

pISSN - 1722-6899

DOI - 10.5301/jabb.2010.6104

Subject(s) - glutaraldehyde , pericardium , freeze drying , materials science , biomedical engineering , scanning electron microscope , chemistry , chromatography , composite material , surgery , medicine

Purpose: Biomaterials have been widely used in the field of regenerative medicine. Bovine pericardium tissue has been successfully used as a bioprosthetic material in manufacturing heart valves, but studies concerning the tissue are ongoing in order to improve its storage, preservation and transportation. This article provides an overview of the characteristics of bovine pericardium tissue chemically treated after the freeze-drying process. These characteristics are essential to evaluate the changes or damage to the tissue during the process. Methods: The mechanical properties of the tissue were analyzed by three different methods due to its anisotropic characteristics. The physical properties were analyzed by a colorimetric method, while the morphological properties were evaluated by scanning electron microscopy (SEM). Results: The freeze-dried bovine pericardium showed no significant change in its mechanical properties. There was no significant change in the elasticity of the tissue (p > 0.05) and no color change. In addition, SEM analysis showed that the freeze-dried samples did not suffer structural collapse. Conclusions: It was concluded that glutaraldehyde-treated bovine pericardium tissue showed no significant change in its properties after the freeze-drying process.State of Sao Paulo Research Foundation (FAPESP

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