NOVEL CELLULAR STAINING PROTOCOL AND ANTIPROLIFERATIVE EFFECT OF VERNONIA AMYGDALINA DELILE ON LUNG AND PROSTATE CANCER CELLS. | Zendy

Clément G. Yedjou | Zendy; Solange S Tchounwou | Zendy; Kathleen Williams | Zendy; Paul B. Tchounwou | Zendy

Open Access

NOVEL CELLULAR STAINING PROTOCOL AND ANTIPROLIFERATIVE EFFECT OF VERNONIA AMYGDALINA DELILE ON LUNG AND PROSTATE CANCER CELLS.

Author(s) -

Clément G. Yedjou,

Solange S Tchounwou,

Kathleen Williams,

Paul B. Tchounwou

Publication year - 2018

Publication title -

zenodo (cern european organization for nuclear research)

Language(s) - English

Resource type - Journals

ISSN - 2277-9655

DOI - 10.5281/zenodo.1403369

Subject(s) - prostate cancer , propidium iodide , lung cancer , vernonia amygdalina , cancer research , cancer , medicine , cancer cell , prostate , dapi , staining , acridine orange , biology , pathology , oncology , traditional medicine , apoptosis , programmed cell death , biochemistry

There is a critical need for more effective therapeutic approaches for cancer. Vernonia amygdalina Delile (VAD) has been used in African traditional medicine for the prevention and/or treatment of several diseases including diarrhea, intestinal illnesses, and cancer. However, the effects of VAD on human lung cancer and human prostate cancer cells remain largely unknown. The aim of this study was to explore a novel cellular staining protocol using acridine orange/propidium iodide (AO/PI) and to test the antiproferative activity of VAD against human lung cancer (A-549) cells and human prostate cancer (PC-3) cells. Our studies demonstrate that VAD inhibits the proliferation of both A-549 and PC-3 cells in a dose-dependent manner. This finding suggests that VAD may be useful in lung and prostate cancer prevention. However, further research is needed to elucidate the chemopreventive effects of VAD against cancer.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research