Genotype Distribution of Vitamin D Receptor Polymorphisms among Indonesian Patients with Chronic Hepatitis B | Zendy

Arfianti Arfianti | Zendy; Athalah Sabillah Sumpena | Zendy; Fauzia Andrini Djojosugito | Zendy; Dita Kartika Sari | Zendy; Ariza Julia Paulina | Zendy

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Genotype Distribution of Vitamin D Receptor Polymorphisms among Indonesian Patients with Chronic Hepatitis B

Author(s) -

Arfianti Arfianti,

Athalah Sabillah Sumpena,

Fauzia Andrini Djojosugito,

Dita Kartika Sari,

Ariza Julia Paulina

Publication year - 2021

Publication title -

reports of biochemistry and molecular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.467

H-Index - 8

ISSN - 2322-3480

DOI - 10.52547/rbmb.9.4.463

Subject(s) - cirrhosis , calcitriol receptor , hepatocellular carcinoma , entecavir , genotype , gastroenterology , single nucleotide polymorphism , medicine , hepatitis b virus , hepatitis b , immunology , vitamin d and neurology , biology , virus , gene , lamivudine , genetics

Chronic hepatitis B is a necro-inflammatory of the liver parenchyma caused by hepatitis B virus (HBV) infection leading to liver cirrhosis and hepatocellular carcinoma (HCC). Genetic variants including single nucleotide polymorphisms (SNPs) within genes regulating immune response may contribute to the progression of chronic hepatitis B (CHB) infection. This study aimed to examine the genotype distribution of vitamin D receptor (VDR) polymorphism among patients with CHB infection and to study its association with the development of cirrhosis and hepatoma.

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