PTGS2 Over-expression: A Colorectal Carcinoma Initiator Not an Invasive Factor | Zendy

Tahereh Zahedi | Zendy; Abasalt Hosseinzadeh Colagar | Zendy; Habibollah Mahmoodzadeh | Zendy

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PTGS2 Over-expression: A Colorectal Carcinoma Initiator Not an Invasive Factor

Author(s) -

Tahereh Zahedi,

Abasalt Hosseinzadeh Colagar,

Habibollah Mahmoodzadeh

Publication year - 2021

Publication title -

reports of biochemistry and molecular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.467

H-Index - 8

ISSN - 2322-3480

DOI - 10.52547/rbmb.9.4.442

Subject(s) - oncology , colorectal cancer , medicine , carcinoma , cancer research , cancer

Cyclooxygenase-2 (COX-2) main product is Prostaglandin E2 (PGE2) which cause mitogenesis and inflammation. COX-2 is the product of prostaglandin-endoperoxide synthase 2 ( PTGS2 ) gene expression. COX-2 dysregulation can cause angiogenesis, differentiation, and promotion of cancer and its suppression related to control of the tumor's size, number, and cell shape. This study focused on the association of COX-2 expression with colorectal carcinoma (CRC) among Iranian patients on mRNA level and in the Cancer Genome Atlas Program (TCGA) colon and rectum RNAseq dataset, and its relation with pathological features.

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