High Resolution Melting Analysis for Evaluation of mir-612 (Rs12803915) Genetic Variant with Susceptibility to Pediatric Acute Lymphoblastic Leukemia | Zendy

Payam Siyadat | Zendy; Hossein Ayatollahi | Zendy; Mahmood Barati | Zendy; Maryam Sheikhi | Zendy; Minoo Shahidi | Zendy

Open Access

High Resolution Melting Analysis for Evaluation of mir-612 (Rs12803915) Genetic Variant with Susceptibility to Pediatric Acute Lymphoblastic Leukemia

Author(s) -

Payam Siyadat,

Hossein Ayatollahi,

Mahmood Barati,

Maryam Sheikhi,

Minoo Shahidi

Publication year - 2021

Publication title -

reports of biochemistry and molecular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.467

H-Index - 8

ISSN - 2322-3480

DOI - 10.52547/rbmb.9.4.385

Subject(s) - high resolution melt , genotype , snp , sanger sequencing , allele , lymphoblastic leukemia , single nucleotide polymorphism , leukemia , polymorphism (computer science) , oncology , genetics , medicine , biology , gene , dna sequencing

Acute lymphoblastic leukemia (ALL) is a highly heterogeneous malignancy that accounts for nearly 75% of leukemias in children. While the exact mechanism of ALL is not fully understood, some genetic variants have been implicated as associated with ALL susceptibility. The association between some genetic variants in miRNA genes and ALL risk has been described previously. A previous study suggested that mir-612 rs12803915 G> A may be associated with pediatric ALL risk. High-resolution melting (HRM) analysis is a reliable method that can be applied for polymorphism detection.

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