Association of Exposure to Polycyclic Aromatic Hydrocarbons with Inflammation, Oxidative DNA Damage and Renal-pulmonary Dysfunctions in Barbecue Makers in Southern Nigeria | Zendy

Augusta Chinyere Nsonwu-Anyanwu | Zendy; Augusta N. Idenyi | Zendy; Sunday Jeremiah Offor | Zendy; Caroline Chinenyenwa Thomas | Zendy; Friday Okputu | Zendy; Clement Emmanuel Edet | Zendy; Chinyere Adanna Opara Usoro | Zendy

Open Access

Association of Exposure to Polycyclic Aromatic Hydrocarbons with Inflammation, Oxidative DNA Damage and Renal-pulmonary Dysfunctions in Barbecue Makers in Southern Nigeria

Author(s) -

Augusta Chinyere Nsonwu-Anyanwu,

Augusta N. Idenyi,

Sunday Jeremiah Offor,

Caroline Chinenyenwa Thomas,

Friday Okputu,

Clement Emmanuel Edet,

Chinyere Adanna Opara Usoro

Publication year - 2022

Publication title -

reports of biochemistry and molecular biology

Language(s) - English

Resource type - Journals

ISSN - 2322-3480

DOI - 10.52547/rbmb.11.1.74

Subject(s) - inflammation , dna damage , oxidative stress , dna , polycyclic aromatic hydrocarbon , medicine , occupational exposure , environmental health , chemistry , environmental chemistry , biochemistry

Multiple organ dysfunctions have been linked to exposure to polycyclic aromatic hydrocarbons (PAH) and oxidative stress (OS), oxidative DNA damage, and inflammatory response to PAH have been implicated. The biomarkers of OS (malondialdehyde (MDA), total plasma peroxide (TPP), total antioxidant capacity (TAC), glutathione (GSH), nitric oxide (NO), oxidative stress index (OSI)); 8-hydroxy-2-deoxyguanosine (8-OHdG)); tumor necrosis factor-alpha (TNF-α)); 1-hydroxy pyrene (1-HOP)), serum and urine creatinine, uric acid (UA), estimated glomerular filtration rate (eGFR) and peak expiratory flow rate (PEFR) were assessed in barbecue makers.

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