Open AccessO6-Methylguanine-DNA Methyltransferase and ATP-Binding Cassette Membrane Transporter G2 Promotor Methylation: Can Predict the Response to Chemotherapy in Advanced Breast Cancer?
Author(s) -
Sarah Ahmed Aglan,
Ahmad Mohamad Zaki,
Amel Sobhy El Sedfy,
Heba Elsheredy,
Ola Elgaddar
Publication year - 2022
Publication title -
reports of biochemistry and molecular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.467
H-Index - 8
ISSN - 2322-3480
DOI - 10.52547/rbmb.11.1.20
Subject(s) - promoter , dna methyltransferase , methyltransferase , dna methylation , methylation , cancer research , breast cancer , transporter , chemotherapy , dna , atp binding cassette transporter , chemistry , biology , microbiology and biotechnology , cancer , genetics , gene , biochemistry , gene expression
ATP-binding cassette membrane transporter G2 (ABCG2) gene is one of transporter family and well characterized for their association with chemoresistance. Promoter methylation is a mechanism for regulation of gene expression. O6-Methyl guanine DNA methyl transferase (MGMT) gene plays a fundamental role in DNA repair. MGMT has the ability to remove alkyl adducts from DNA at the O6 position of guanine. Alkylating agents exert their function through adding these alkyls adducts to DNA leading to cell death unless it is repaired by MGMT. MGMT promoter was found to be methylated in several malignancies. The aim of the present work is to study the relation of MGMT and ABCG2 promoter methylation status in advanced breast cancer patients to response to cyclophosphamide-doxorubicin (AC) based therapeutic regime.
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