Association Between NOX4 And Nrf2 Genes in Non-Small-Cell Lung Carcinoma: A Case-Control Study | Zendy

Nasim Bakhtiyari | Zendy; Akbar Sharifi | Zendy; Younes Aftabı | Zendy; Neda Gilani | Zendy; Venus Zafari | Zendy; Atefeh Ansarin | Zendy; Ensiyeh Seyedrezazadeh | Zendy

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Association Between NOX4 And Nrf2 Genes in Non-Small-Cell Lung Carcinoma: A Case-Control Study

Author(s) -

Nasim Bakhtiyari,

Akbar Sharifi,

Younes Aftabı,

Neda Gilani,

Venus Zafari,

Atefeh Ansarin,

Ensiyeh Seyedrezazadeh

Publication year - 2021

Publication title -

reports of biochemistry and molecular biology

Language(s) - English

Resource type - Journals

ISSN - 2322-3480

DOI - 10.52547/rbmb.10.2.327

Subject(s) - nox4 , lung cancer , bronchoalveolar lavage , biology , western blot , messenger rna , lung , carcinoma , cancer research , medicine , microbiology and biotechnology , pathology , endocrinology , nadph oxidase , gene , oxidative stress , biochemistry

Epithelial malignancy in lung cancer, which is initiated with myofibroblast differentiation and remodeling, promotes hypoxia and intracellular ROS generation most affected by the prototypical enzyme, NADPH oxidase 4 ( NOX4 ). In addition, nuclear factor erythroid 2-related factor 2 ( Nrf2 ) acts as a critical transcription factor by stimulating antioxidant proteins as redox homeostasis regulators. The aim of this study was to investigate a possible correlation between lung tissue NOX4 and Nrf2 genes ( NOX4 and Nrf2 ) mRNA expression and bronchoalveolar lavage fluid (BALF) protein expression in non-small-cell lung carcinoma (NSCLC) patients.

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