Association of IL-15 and IP-10 Serum Levels with Cytomegalovirus Infection, CMV Viral Load and Cyclosporine Level after Kidney Transplantation | Zendy

Reza Asadzadeh | Zendy; Pedram Ahmadpoor | Zendy; Mohsen Nafar | Zendy; Shima Samavat | Zendy; Hassan Nikoueinejad | Zendy; Morteza Hosseinzadeh | Zendy; Nahid Mamizadeh | Zendy; Saeideh Hatami | Zendy; Elham Masoumi | Zendy; Aliakbar Amirzargar | Zendy

Open Access

Association of IL-15 and IP-10 Serum Levels with Cytomegalovirus Infection, CMV Viral Load and Cyclosporine Level after Kidney Transplantation

Author(s) -

Reza Asadzadeh,

Pedram Ahmadpoor,

Mohsen Nafar,

Shima Samavat,

Hassan Nikoueinejad,

Morteza Hosseinzadeh,

Nahid Mamizadeh,

Saeideh Hatami,

Elham Masoumi,

Aliakbar Amirzargar

Publication year - 2021

Publication title -

reports of biochemistry and molecular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.467

H-Index - 8

ISSN - 2322-3480

DOI - 10.52547/rbmb.10.2.216

Subject(s) - immunology , viral load , immune system , transplantation , kidney transplantation , cytomegalovirus , human cytomegalovirus , cytokine , medicine , biology , virus , viral disease , herpesviridae

Cytomegalovirus (CMV) infection is the most common complications following kidney transplantation. Natural killer (NK) cells demonstrated critical anti-viral role in controlling and elimination of CMV after transplantation. Interleukin-15 (IL-15) is a pleiotropic cytokine that promotes the activity of NK cells and strengthens the acquired immune system. Also, IP10 (CXCL10) is a chemotactic factor which regulates NK cell recruitment and antiviral immune response. We aimed to determine the correlation between the serum levels of IL-15 and IP-10 cytokines with CMV infection, CMV viral load, and cyclosporine as a major immunosuppressive treatment after transplantation.

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