Efficacy of Photobiomodulation and Metformin on Diabetic Cell Line of Human Periodontal Ligament Stem Cells through Keap1/Nrf2/Ho-1 Pathway | Zendy

Latifa Mohamed Abdelgawad | Zendy; Manar Mohy Abd El-hamed | Zendy; Dina Sabry | Zendy; Marwa Abdelgwad | Zendy

Open Access

Efficacy of Photobiomodulation and Metformin on Diabetic Cell Line of Human Periodontal Ligament Stem Cells through Keap1/Nrf2/Ho-1 Pathway

Author(s) -

Latifa Mohamed Abdelgawad,

Manar Mohy Abd El-hamed,

Dina Sabry,

Marwa Abdelgwad

Publication year - 2021

Publication title -

reports of biochemistry and molecular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.467

H-Index - 8

ISSN - 2322-3480

DOI - 10.52547/rbmb.10.1.30

Subject(s) - periodontal ligament stem cells , viability assay , oxidative stress , metformin , mtt assay , glycation , diabetes mellitus , medicine , cell growth , cell , chemistry , endocrinology , alkaline phosphatase , biochemistry , enzyme

Diabetes mellitus (DM) is a metabolic disorder resulting from hyperglycemia. Hyperglycemia contributes to oxidative stress, and the release of advanced glycation end products (AGEs) further promotes disease pathogenesis. Uncontrolled diabetes reflects great oral complications and affects human oral health. So, the present study aimed to assess the effects of photobiomodulation therapy (PBMT) and Metformin on proliferation and viability of human periodontal ligament stem cells (HPDLSCs) cultured in high glucose medium.

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