The Role of Cellular Membrane Microvesicles in Acute Myelogenous Leukemia | Zendy

Yue Wang | Zendy; Yangfang Chen | Zendy

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The Role of Cellular Membrane Microvesicles in Acute Myelogenous Leukemia

Author(s) -

Yue Wang,

Yangfang Chen

Publication year - 2020

Publication title -

isp medicine

Language(s) - English

Resource type - Journals

ISSN - 2693-0226

DOI - 10.52274/ispmed20200213

Subject(s) - microvesicles , haematopoiesis , disease , leukemia , cancer research , medicine , biomarker , progenitor cell , bone marrow , cancer , pathogenesis , immunology , stem cell , biology , microrna , pathology , microbiology and biotechnology , biochemistry , gene

Little is known about the role of cellular membrance microvesicles (MVs) in hematological malignancies, especially acute myelogenous leukemia (AML), a malignant disease characterized by uncontrolled proliferation of hematopoietic stem or progenitor cells, which can lead to bone marrow failure and eventually to death. The role of MVs in the pathogenesis of cancer has been reported previously. In this review, we summarized the current progress of MVs in AML, and their roles as potential biomarkers and therapeutically targets for this research area. In summary, we found that MVs may represent a novel biomarker for disease diagnosis and response to treatment, indicators of disease status and severity, as well as potential active modulator for driving drug resistance. Further studies are needed to better understanding deeply about the role of MVs in AML.

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