Bone adaptation to simultaneous cadmium and diazinon toxicity in adult male rats | Zendy

Hana Chovancová | Zendy; Radoslav Omelka | Zendy; Ivana Boboňová | Zendy; Grzegorz Formicki | Zendy; R. Toman | Zendy; Monika Martiniaková | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Bone adaptation to simultaneous cadmium and diazinon toxicity in adult male rats

Author(s) -

Hana Chovancová,

Radoslav Omelka,

Ivana Boboňová,

Grzegorz Formicki,

R. Toman,

Monika Martiniaková

Publication year - 2014

Publication title -

potravinarstvo slovak journal of food sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.259

H-Index - 12

eISSN - 1338-0230

pISSN - 1337-0960

DOI - 10.5219/343

Subject(s) - diazinon , toxicity , femoral neck , bone remodeling , endocrinology , cadmium , medicine , adult male , physiology , body weight , cortical bone , osteoporosis , zoology , biology , anatomy , chemistry , pesticide , ecology , organic chemistry

Food contamination from natural or anthropogenic sources poses severe risks to health of human and animals. Bone is a metabolically active organ, which can be affected by various toxic substances, such as cadmium (Cd) and diazinon (DZN), leading to disruption in bone metabolic processes. The present study was designed to investigate the effect of simultaneous peroral administration to Cd and DZN on femoral compact bone structure in adult male rats. A total of twenty 1-month-old male Wistar rats were randomized into two experimental groups. In the first group (EG), young males were dosed with a combination of 30 mg CdCl2/L and 40 mg DZN/L in drinking water, for 90 days. Ten 1-month-old males without Cd-DZN intoxication served as a control group (CG). After 90 days of daily peroral exposure, evaluations of femoral bone macro- and micro-structure were performed in each group. We found no significant differences in body weight, femoral weight, femoral length and cortical bone thickness between both groups (EG and CG). However, rats from the group EG displayed different microstructure in the middle part of the substantia compacta where primary vascular radial bone tissue appeared. In some cases, vascular expansion was so enormous that canals were also present near the periost. On the other hand, they occurred only near endosteal surfaces in rats from the control group. Moreover, a smaller number of primary and secondary osteons was identified in Cd-DZN-exposed rats. This fact signalizes reduced mechanical properties of their bones. Anyway, our results suggest an adaptive response of compact bone tissue to Cd-DZN-induced toxicity in adult male rats in order to prevent osteonecrosis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research