Nutrigenomic analysis of C677T mutation of MTHFR gene in Slovak population | Zendy

Radoslav Židek | Zendy; Jozef Golian | Zendy; J. Bulla | Zendy

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Nutrigenomic analysis of C677T mutation of MTHFR gene in Slovak population

Author(s) -

Radoslav Židek,

Jozef Golian,

J. Bulla

Publication year - 2011

Publication title -

potravinarstvo slovak journal of food sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.259

H-Index - 12

eISSN - 1338-0230

pISSN - 1337-0960

DOI - 10.5219/136

Subject(s) - methylenetetrahydrofolate reductase , mutant , genotype , heterozygote advantage , mutation , biology , genetics , allele , population , gene , medicine , environmental health

Total of 124 individuals originated from Slovak Republic has been nutrignomically analysed. Analysis was focused to mutation C677T of MTHFR gene detection and analysis of mutant genotypes frequency. Observed frequency of allele 677C was 0.6998 and allelic frequency of mutant variant 677T was 0.3992. Genotype frequency of mutant heterozygotes with 71% activity of MTHFR enzyme was 0,391 and mutant homozygotes with 33% MTHFR enzyme activity was 0.153. Result shows 64% of Slovak has decreased activity of enzyme MTHFR, and 14.3% of Slovak has predisposition to cancer, cardio vascular diseases, loss of fertility and many others complications according to improper nutrition, low folic acid and B12 vitamin intake. doi:10.5219/136

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