AVALIAÇÃO CLÍNICA TOXICÓLOGICA PRELIMINAR DO VITICROMIN EM PACIENTES COM VITILIGO

The Brosimum gaudichaudii Trecul (Moraceae) is a very common herb in brazilian vegetation called "Cerrado". This plant is used in the ethnopharmacology for the treatment of the vitiligo. In this plant are founded the furancoumarins, mainly psoralen and bergapten which have a photosensibility property responsible for the dermal repigmentation effect. The Brosimum gaudichaudii is a main active component of a medicine called as Viticromin®, which is made from the inferior part of the stem and the roots of the plant. Considering the low toxicity of the Brosimum gaudichaudii's roots extract in the pre-clinical toxicological studies, in this study we investigated same parameters of the clinical toxicology of the Viticromin® in vitiligo's patients on therapy with this drug. The results showed that this drug produced no significant alteration on the aspects investigated in patients under the drug regimen studied.