New roles for EPHB4 in prostate cancer

This thesis presents insight into the signalling pathways of EphB4, a protein known to be involved in cancer progression. A new method was developed and used to identify a number of proteins that can interact with EphB4; and a novel mechanism of action for EphB4 was identified, where EphB4 was transported outside of the host cell by small vesicles called exosomes. These findings suggest that EphB4 may play important roles in pathways in both normal and disease states, and opens up new research directions into understanding the mechanisms, signalling pathways and cellular consequences of these new roles for EphB4