Bone Tissue Engineering in Two Preclinical Ovine Animal Models | Zendy

Jan Henkel | Zendy

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Bone Tissue Engineering in Two Preclinical Ovine Animal Models

Author(s) -

Jan Henkel

Publication year - 2017

Language(s) - English

Resource type - Dissertations/theses

DOI - 10.5204/thesis.eprints.109909

Subject(s) - tissue engineering , scaffold , biomedical engineering , bench to bedside , bone tissue , medicine , animal model , computer science , engineering , medical physics

This PhD-research was focused on the development and evaluation of innovative scaffold-based bone tissue engineering concepts for the treatment of large volume bone defects, which still represent a major challenge in orthopaedic and reconstructive surgery. Two different types of bone tissue engineering constructs were investigated and successfully applied to regenerate critically-sized segmental bone defects in ovine animal models. The results outlined in the PhD thesis represent a significant contribution to potential future clinical translations of bone tissue engineering concepts from bench to bedside

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