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Background: Vatavyadhis has been mentioned as one of the Ashtomahagada due to its notorious nature. Being a Vatavyadhi, located in Marma Asthi and Sandhi and its occurrence in old age makes it Kashta sadhya. Osteoarthritis is most common degenerative and disabling disorder in majority of people in 5-6th decade of life.There is only conservative treatment giving short term relief in pain and surgical intervention with lots of side effects..Sushruta has mentioned Agnikarma as best treatment for vata Kaphaj Vyadhis.Charaka, has mentioned Basti made up of Tikta Dravya, Ghrita and Kshira in Asthidhatu Dushti,. Keeping all these things in view Agnikarma and Panchatikta guggulu were selected for the treatment of Janusandhigatavata. To evaluate the efficacy of Agnikarma and Panchatikta Guggulu in management of Janusandhigatavata (osteoarthritis of knee joint). Methods: Total 43 diagnosed cases of osteoarthritis were registered out of which 41 patient completed the study .In group A 4 sittings of Agnikarma was done in 21 patients with Panchadhatu Shalaka.In group B 4 sittings of Agnikarma was done in 20 patients with Panchadhatu Shalaka along with Panchatikta Guggulu orally for 1 month. Result: The result was assessed by using wilcoxan, paired t test, Mann Whitney and unpaired t test.Significant relief was observed in both groups in all parameters. Clinically and percentage wise group B had shown better results. Conclusion: Study was concluded that Agnikarma alone has a definite role in reducing the knee joint pain and tenderness but addition of Panchatikta Guggulu found convincing results in stiffness, swelling and (ROM) of knee joint.

Effect of Agnikarma along with Panchatikta Guggulu in the management ofJanusandhigatavata (Osteoarthritis of Knee Joint)