Cloning of the DNA Vaccine Candidate LACK Gene of Leishmania infantum | Zendy

Serkan Karaca | Zendy; Şirin Sahra Ceylan | Zendy; Süleyman Yazar | Zendy; Salih Kuk | Zendy

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Cloning of the DNA Vaccine Candidate LACK Gene of Leishmania infantum

Author(s) -

Serkan Karaca,

Şirin Sahra Ceylan,

Süleyman Yazar,

Salih Kuk

Publication year - 2016

Publication title -

turkish journal of parasitology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.207

H-Index - 18

eISSN - 2146-3077

pISSN - 1300-6320

DOI - 10.5152/tpd.2016.3743

Subject(s) - leishmania infantum , plasmid , biology , recombinant dna , dna vaccination , genomic dna , leishmania , virology , gene , cloning (programming) , molecular cloning , dna sequencing , visceral leishmaniasis , leishmaniasis , microbiology and biotechnology , genetics , peptide sequence , parasite hosting , world wide web , computer science , programming language

Leishmaniasis is caused by an obligate intracellular protozoa belonging to Leishmania genus and listed among major tropical diseases by WHO. Because of the high costs, toxicity, and adverse effects of routinely used compounds in the treatment, alternative treatment and vaccine studies are underway. An effective vaccine has not been developed to date. In this study, we aimed to clone one of the most promising DNA vaccine candidates: the homolog-activated C kinase (LACK) gene of Leishmania infantum.

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