Primary Cutaneous Blastomycosis Responding to Itraconazole: Case Report

Primary cutaneous blastomycosis (PCB) is a rare fungal infection that is caused by direct skin inoculation of Blastomyces dermatitides with trauma. Clinically, the lesions generally start as a chancre at the trauma site, and these lesions may be associated with lymphadenopathy and lymphangitis. The criteria for diagnosis of PCB are; (i) the presence of characteristic skin lesions and lymphadenopathy or lymphangitis, (ii) a history of inoculation of fungus, (iii) no evidence of systemic involvement (before, during or after presentation), (iiii) culture or direct smear demonstrating the organisms in the skin lesions or lymph nodes. Here, we present a female patient diagnosed as PCB according to the history and histopathologic findings who responded to itraconazole. (Turk J Dermatol 2010; 4: 81-3)