Cryoglobulinemic neuropathy: a treatable cause of polyneuropathy

We report a case of a 62 year-old woman who presented with progressive, asymmetric dysesthesias over 1 year. She was previously diagnosed with idiopathic neuropathy and sought a second opinion. Electrodiagnostic studies revealed an asymmetric, sensory neuropathy. Laboratory studies revealed cryoglobulinemia associated with hepatitis C infection. She underwent treatment with ribavirin and interferon (Gilead Sciences). Her hepatitis studies were undetectable and her neuropathic symptoms resolved. We review the presentation of cryoglobulinemic neuropathy. Emphasis is placed on considering this treatable cause of neuropathy, which may be under-recognized.