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Corresponding Author: Bilgin Öztürk E-mail: drbilgin@gmail.com Submitted: 11 July 2017 Accepted: 24 October 2017 You may cite this article as: Karadaş Ö, Öztürk B, İnan L, İnan N. Comparison of single and repeated blockade of the greater occipital nerve in migraine treatment. Neurol Sci Neurophysiol 2018; 35: 97-101. Abstract Objective: Migraine is a neurovascular syndrome that can be triggered by several conditions such as increased stress levels, sleep disorders, some foods, hormonal abnormalities, and weather changes. In this study, the efficacy of single and repetitive greater occipital nerve blockade on patients with migraine were investigated.