Role of First Trimester Sex Hormone-Binding Globuline and High-Sensitivity C-Reactive Protein in Predicting Gestational Diabetes Mellitus

Objective: We aimed to evaluate the role of sex hormone-binding protein and high-sensitivity C-reactive protein for predicting gestational diabetes mellitus. Methods: A total of 99 pregnant women between 6th and 14th gestational weeks who were admitted to our obstetrics and gynecology outpatient clinic between February 2017 and July 2017 were included. Age, gestational week, last menstrual date, gravida, parity, height, weight, history of gestational diabetes mellitus, macrosomia and polyhydramnios, tobacco use, delivery mode, delivery weight, sex hormone-binding protein, and high-sensitivity C-reactive protein levels were recorded. Results: No difference between gestational diabetes and control group with regard to age, gravida, parity, gestational age at delivery and tobacco use (p>0.05) was noted. Body mass index, history of gestational diabetes, macrosomia and polyhydramnios, birth weight and cesarean rates were significantly higher in gestational diabetes group. Sex hormone-binding protein levels were 213.4±111.33 nmol/L in gestational diabetes and 251.64±137.94 nmol/L in control group, which were not significatly different between two groups (p=0.325). High-sensitivity C-reactive protein levels were 10.12±11.36 mg/L in gestational diabetes and 5.18±5.91 mg/L in control group and statistically significant difference was noted between two groups (p=0.004). High-sensitivity C-reactive protein >3.25 mg/L was found to be a predictor for gestational diabetes with a sensitivity of 78% and specifity of 62%. Conclusion: First trimester high-sensitivity C-reactive protein was found to be a predictor for gestational diabetes mellitus in which early diagnosis has a critical role for reducing maternal and fetal mortality and morbidity.