Audiological and Vestibular Findings in Subjects with MELAS Syndrome | Zendy

Dan Dupont Hougaard | Zendy; Danjal Hofgaard Hestoy | Zendy; Allan Thomas Højland | Zendy; Michael Gaihede | Zendy; Michael B. Petersen | Zendy

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Audiological and Vestibular Findings in Subjects with MELAS Syndrome

Author(s) -

Dan Dupont Hougaard,

Danjal Hofgaard Hestoy,

Allan Thomas Højland,

Michael Gaihede,

Michael B. Petersen

Publication year - 2019

Publication title -

the journal of international advanced otology

Language(s) - English

Resource type - Journals

eISSN - 2148-3817

pISSN - 1308-7649

DOI - 10.5152/iao.2019.5913

Subject(s) - audiology , vestibular system , melas syndrome , medicine , mitochondrial myopathy , biology , mitochondrial dna , genetics , gene

The mitochondrial DNA (mtDNA) point mutation m.3243A>G is known to express the following two syndromes among others: maternally inherited diabetes and deafness (MIDD) and mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Sensorineural hearing loss (SNHL) is the most frequent symptom in individuals harboring the m.3243A>G mutation. However, dysfunction of the vestibular organs has been scarcely examined. Therefore, the present study aimed to study the impact of the m.3243A>G mutation on the inner ear.

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