Tricellulin Expression and its Deletion Effects in the Endolymphatic Sac | Zendy

Ai Matsubara | Zendy; Takenori Miyashita | Zendy; Ryuhei Inamoto | Zendy; Hirofumi Sakaguchi | Zendy; Toru Kamitani | Zendy; Nozomu Mori | Zendy

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Tricellulin Expression and its Deletion Effects in the Endolymphatic Sac

Author(s) -

Ai Matsubara,

Takenori Miyashita,

Ryuhei Inamoto,

Hirofumi Sakaguchi,

Toru Kamitani,

Nozomu Mori

Publication year - 2018

Publication title -

the journal of international advanced otology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.518

H-Index - 13

eISSN - 2148-3817

pISSN - 1308-7649

DOI - 10.5152/iao.2018.5473

Subject(s) - endolymphatic sac , tight junction , immunohistochemistry , cochlea , h&e stain , barrier function , pathology , chemistry , microbiology and biotechnology , inner ear , biology , anatomy , medicine

Tricellulin is a tight junction (TJ)-forming protein that participates in the sealing function of tricellular TJs. Tricellulin-knockout (Tric-/-) mice show progressive hearing loss with degeneration of hair cells in the cochlea without physiological or physical disorders. In the present study, we investigated the tricellulin expression and its deletion effects in the endolymphatic sac (ES) using Tric-/- mice.

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