Single Administration of a Sustained-Release Formulation of KB-R7785 Inhibits Tympanic Membrane Regeneration in an Animal Model | Zendy

Peter L. Santa Maria | Zendy; Chloe Santa Maria | Zendy; Sung Woo Kim | Zendy; Yunzhi Yang | Zendy

Open Access

Single Administration of a Sustained-Release Formulation of KB-R7785 Inhibits Tympanic Membrane Regeneration in an Animal Model

Author(s) -

Peter L. Santa Maria,

Chloe Santa Maria,

Sung Woo Kim,

Yunzhi Yang

Publication year - 2016

Publication title -

the journal of international advanced otology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.518

H-Index - 13

eISSN - 2148-3817

pISSN - 1308-7649

DOI - 10.5152/iao.2016.3124

Subject(s) - medicine , granulation tissue , perforation , membrane , surgery , tympanic membrane perforation , regeneration (biology) , anesthesia , tympanoplasty , wound healing , biology , punching , materials science , metallurgy , genetics , microbiology and biotechnology

A pressure equalization tube placed within the tympanic membrane is the only clinically available method for inhibiting tympanic membrane regeneration. Problems associated with this include associated otorrhea, biofilm formation, medial migration of the tube, tube retention, induction of granulation tissue, and a small but significant rate of cholesteatoma. We aimed to demonstrate that a single administration of a sustained-release polymer formulation of KB-R7785 maintains tympanic membrane perforation for at least 6 months.

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