Apoptotic Effects of Sanguinarine on the Organ of Corti 1 Cells: Comparison with Cisplatin | Zendy

Emre Çeçen | Zendy; Pınar Erçetin | Zendy; Günay Kırkım | Zendy; Ayça Pamukoğlu | Zendy; Safiye Aktaş | Zendy; Zekiye Altun | Zendy; Ersoy Doğan | Zendy; Nur Olgun | Zendy

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Apoptotic Effects of Sanguinarine on the Organ of Corti 1 Cells: Comparison with Cisplatin

Author(s) -

Emre Çeçen,

Pınar Erçetin,

Günay Kırkım,

Ayça Pamukoğlu,

Safiye Aktaş,

Zekiye Altun,

Ersoy Doğan,

Nur Olgun

Publication year - 2015

Publication title -

the journal of international advanced otology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.518

H-Index - 13

eISSN - 2148-3817

pISSN - 1308-7649

DOI - 10.5152/iao.2015.484

Subject(s) - sanguinarine , apoptosis , viability assay , pharmacology , cisplatin , annexin , medicine , necrosis , biology , alkaloid , pathology , biochemistry , botany , chemotherapy

Sanguinarine is an alkaloid obtained from the root of Sanguinaria canadensis and other plants from the Papaveraceae family and is well known to possess a broad range of biological functions, such as antimicrobial, antifungal, anti-inflammatory, and antineoplastic activities. We aimed to specify the in vitro effect of sanguinarine on the House Ear Institute-Organ of Corti 1 (HEI-OC1) cells and to compare this effect with the ototoxic effect of cisplatin (CDDP).

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