Effect of Transtympanic Injection of Melatonin on Cisplatin-Induced Ototoxicity | Zendy

Mehmet Gökhan Demir | Zendy; Niyazi Altıntoprak | Zendy; Sedat Aydın | Zendy; Ebru Kösemihal | Zendy; Kayhan Başak | Zendy

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Effect of Transtympanic Injection of Melatonin on Cisplatin-Induced Ototoxicity

Author(s) -

Mehmet Gökhan Demir,

Niyazi Altıntoprak,

Sedat Aydın,

Ebru Kösemihal,

Kayhan Başak

Publication year - 2016

Publication title -

the journal of international advanced otology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.518

H-Index - 13

eISSN - 2148-3817

pISSN - 1308-7649

DOI - 10.5152/iao.2015.1094

Subject(s) - ototoxicity , melatonin , medicine , cisplatin , intraperitoneal injection , auditory brainstem response , saline , otoacoustic emission , hearing loss , anesthesia , pharmacology , endocrinology , audiology , chemotherapy

Cisplatin is a chemotherapeutic agent that is widely used in cancer treatment. Numerous side effects have been detected, one of which is ototoxicity. Melatonin, a product of the pineal gland, has a neuroendocrinoimmunological role in vertebrates. In the present study, we investigated the effects of melatonin on cisplatin-induced ototoxicity.

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