The Protective Effect of Intratympanic Alpha Lipoic Acid on Cisplatin-Induced Ototoxicity on Rats | Zendy

Niyazi Altıntoprak | Zendy; Sedat Aydın | Zendy; Arif Şanlı | Zendy; Zekiye Eda Bilmez | Zendy; Ebru Kösemihal | Zendy

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The Protective Effect of Intratympanic Alpha Lipoic Acid on Cisplatin-Induced Ototoxicity on Rats

Author(s) -

Niyazi Altıntoprak,

Sedat Aydın,

Arif Şanlı,

Zekiye Eda Bilmez,

Ebru Kösemihal

Publication year - 2015

Publication title -

the journal of international advanced otology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.518

H-Index - 13

eISSN - 2148-3817

pISSN - 1308-7649

DOI - 10.5152/iao.2014.369

Subject(s) - medicine , ototoxicity , alpha lipoic acid , pharmacology , cisplatin , audiology , oxidative stress , chemotherapy

MATERIALS and METHODS: A total of 24 Wistar albino rats were randomly divided into three groups: group 1 received intraperitoneal (IP) saline + intratympanic (IT) saline as a control group for 4 days (n=8), group 2 received IP cisplatin (20 mg/kg) + IT saline (0.1-0.3 mL) for 4 days (n=8), and group 3 received IP cisplatin (20 mg/kg) + IT α-LA (25 mg/mL) for 4 days (n=8). DPOAEs were performed prior to the procedure and at the end of the experiment on day 5.

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