The Effect of Alpha-Lipoic Acid on Myringosclerosis in a Rat Model | Zendy

Arzu Tatar | Zendy; Özgür Yörük | Zendy; Deniz Ünal | Zendy; Jale Selli | Zendy; Muhammed Yayla | Zendy; Zekai Halıcı | Zendy

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The Effect of Alpha-Lipoic Acid on Myringosclerosis in a Rat Model

Author(s) -

Arzu Tatar,

Özgür Yörük,

Deniz Ünal,

Jale Selli,

Muhammed Yayla,

Zekai Halıcı

Publication year - 2015

Publication title -

the journal of international advanced otology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.518

H-Index - 13

eISSN - 2148-3817

pISSN - 1308-7649

DOI - 10.5152/iao.2014.127

Subject(s) - medicine , alpha lipoic acid , alpha (finance) , lipoic acid , pharmacology , dermatology , surgery , biochemistry , antioxidant , oxidative stress , chemistry , construct validity , patient satisfaction

RESULTS: In histopathological examinations, a high dose (50 mg/kg/day) of the ALA-applied group had histopathological results similar to those of the healthy group. In this group, we detected minimal collagen deposition, slight thickness in the lamina propria, and minimal epithelial disruption. In biochemical examinations, the maximum values of superoxide dismutase and glutathione peroxidase were observed in the group that received 50 mg/kg/day of ALA. CONCLUSION: In this study, the effect of ALA on myringosclerosis development was observed when a dose of 50 mg/kg/day was administered, and a recovery that showed a nearly intact tympanic membrane occurred at the end of 15 days of use. If an antioxidant were to be added to the treatment protocol of tympanic membrane defects, ALA may be a good candidate.

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