Frequency of Rearrangements Versus Small Indels Mutations in BRCA1 and BRCA2 Genes in Turkish Patients with High Risk Breast and Ovarian Cancer | Zendy

Hülya Yazıcı | Zendy; Seda Kılıç | Zendy; Demet Akdeniz | Zendy; Özge Şükrüoğlu Erdoğan | Zendy; Şeref Buğra Tunçer | Zendy; Mukaddes Avsar | Zendy; Gözde Kuru Türkcan | Zendy; Betül Çelik | Zendy; Seden Küçücük | Zendy; Pınar Saip | Zendy

Open Access

Frequency of Rearrangements Versus Small Indels Mutations in BRCA1 and BRCA2 Genes in Turkish Patients with High Risk Breast and Ovarian Cancer

Author(s) -

Hülya Yazıcı,

Seda Kılıç,

Demet Akdeniz,

Özge Şükrüoğlu Erdoğan,

Şeref Buğra Tunçer,

Mukaddes Avsar,

Gözde Kuru Türkcan,

Betül Çelik,

Seden Küçücük,

Pınar Saip

Publication year - 2017

Publication title -

meme sağlığı dergisi/meme sağlığı dergisi

Language(s) - English

Resource type - Journals

eISSN - 1306-0953

pISSN - 1306-0945

DOI - 10.5152/ejbh.2017.3799

Subject(s) - breast cancer , multiplex ligation dependent probe amplification , oncology , ovarian cancer , medicine , cancer , turkish population , genetic counseling , gynecology , gene , genetics , biology , genotype , exon

The current rearrangement ratio of BRCA1 and BRCA2 genes is not known in the Turkish population. Rearrangements are not routinely investigated in many Turkish laboratories. This creates problems and contradictions between clinics. Therefore, the aim of this study was to evaluate the distribution and frequency of rearrangements in BRCA1 and BRCA2 genes in high-risk families and to clarify the limits of BRCA1 and BRCA2 testing in Turkey.

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