Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats | Zendy

Abdulmecit Albayrak | Zendy; Hamit Hakan | Zendy; Halis Süleyman | Zendy

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Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

Author(s) -

Abdulmecit Albayrak,

Hamit Hakan,

Halis Süleyman

Publication year - 2015

Publication title -

eurasian journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.337

H-Index - 13

eISSN - 1308-8742

pISSN - 1308-8734

DOI - 10.5152/eajm.2014.0034

Subject(s) - moclobemide , pharmacology , medicine , malondialdehyde , superoxide dismutase , antidepressant , antioxidant , nitric oxide , glutathione , oxidative stress , chemistry , biochemistry , enzyme , hippocampus

Even though there are many drugs for the treatment of gastric ulcers, these drugs sometimes cannot succeed. Since the 1950s, antidepressant drugs have been used for several non-psychiatric indications. Many antidepressant drugs have been shown experimentally to produce antiulcer activity in various ulcer models. Moclobemide is an antidepressant drug which inhibits monoamine oxidase-A (MAO) enzyme selectively. When it is compared to the classic antidepressants drugs, moclobemide is the first choice in depression treatment because of its effectiveness and less side effects. This study aimed to investigate the antiulcer effects of moclobemide and to determine its relationship with antioxidant mechanisms in rat gastric tissue.

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