The Effects of Erdosteine and N-Acetylcysteine on Apoptotic and Antiapoptotic Markers in Pulmonary Epithelial Cells in Sepsis | Zendy

Rezan Demiralay | Zendy; Nesrin Gürsan | Zendy; Havva Erdem | Zendy

Open Access

The Effects of Erdosteine and N-Acetylcysteine on Apoptotic and Antiapoptotic Markers in Pulmonary Epithelial Cells in Sepsis

Author(s) -

Rezan Demiralay,

Nesrin Gürsan,

Havva Erdem

Publication year - 2013

Publication title -

eurasian journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.337

H-Index - 13

eISSN - 1308-8742

pISSN - 1308-8734

DOI - 10.5152/eajm.2013.35

Subject(s) - acetylcysteine , apoptosis , lipopolysaccharide , pharmacology , tunel assay , medicine , caspase 3 , intraperitoneal injection , antioxidant , immunology , chemistry , programmed cell death , biochemistry

This study investigated the frequency of apoptosis in rat pulmonary epithelial cells after the injection of an intraperitoneal endotoxin lipopolysaccharide (LPS), the effects of LPS on apoptotic (bax, caspase-3) and antiapoptotic (bcl-2) markers during lung damage, and the protective effects of two known antioxidant agents, erdosteine and N-acetylcysteine (NAC).

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