Analysis of dux4 expression in bone marrow and re-discussion of dux4 function in the health and disease | Zendy

Ceren Hangül | Zendy; Oznur Tokta | Zendy; Sibel Berker Karaüzüm | Zendy; Bahar Akkaya | Zendy; Hülya Tosun Yıldırım | Zendy; Funda Tayfun Küpesiz | Zendy; Ayse Nur Akinel | Zendy

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Analysis of dux4 expression in bone marrow and re-discussion of dux4 function in the health and disease

Author(s) -

Ceren Hangül,

Oznur Tokta,

Sibel Berker Karaüzüm,

Bahar Akkaya,

Hülya Tosun Yıldırım,

Funda Tayfun Küpesiz,

Ayse Nur Akinel

Publication year - 2021

Publication title -

turkish journal of pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.305

H-Index - 14

eISSN - 1309-5730

pISSN - 1018-5615

DOI - 10.5146/tjpath.2021.01564

Subject(s) - bone marrow , somatic cell , facioscapulohumeral muscular dystrophy , immunohistochemistry , pathology , haematopoiesis , biology , transcription factor , cancer research , microbiology and biotechnology , medicine , stem cell , gene , genetics

DUX4 is an embryonic transcription factor (TF) later silenced in somatic tissues, while active in germline testis cells. Re-expression in somatic cells has been revealed to be present in pathologic conditions such as dystrophy, leukemia, and other cancer types. Embryonic cells, cancer cells and testis cells that show DUX4 expression are pluri-multipotent cells. This lead us to question "Could DUX4 be a TF that is active in certain types of potent somatic cells?" As a perfect reflection of the potent cell pool, we aimed to reveal DUX4 expression in the bone marrow.

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