Clinicopathologic and molecular analysis of inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma: a case report and review of literature | Zendy

Bryan MoralesVargas | Zendy; Kristin K. Deeb | Zendy; Deniz Peker | Zendy

Open Access

Clinicopathologic and molecular analysis of inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma: a case report and review of literature

Author(s) -

Bryan MoralesVargas,

Kristin K. Deeb,

Deniz Peker

Publication year - 2021

Publication title -

turkish journal of pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.305

H-Index - 14

eISSN - 1309-5730

pISSN - 1018-5615

DOI - 10.5146/tjpath.2021.01523

Subject(s) - sarcoma , follicular dendritic cells , inflammatory pseudotumor , pathology , follicular phase , medicine , neoplasm , spleen , biology , immunology , t cell , immune system , antigen presenting cell , lesion

Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell (FDC/FRC) sarcoma is an extremely rare neoplasm of the spleen associated with EBV and characterized by spindle cell morphology, dense mixed chronic inflammatory background, and a broad immunophenotypic profile often causing a diagnostic challenge for pathologists. The molecular features of FDC/FRC sarcoma are largely unknown due to a lack of comprehensive data. Here we present the results of next-generation sequencing and Single Nucleotide Polymorphism Copy Number array analysis in a case of FDC/FRC and review the literature.

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