Clinicopathological and prognostic significance of the eml4-alk translocation and igfr1, ttf1, napsin a expression in patients with lung adenocarcinoma | Zendy

Pınar Bulutay | Zendy; Nalân Akyürek | Zendy; Leyla Memış | Zendy

Open Access

Clinicopathological and prognostic significance of the eml4-alk translocation and igfr1, ttf1, napsin a expression in patients with lung adenocarcinoma

Author(s) -

Pınar Bulutay,

Nalân Akyürek,

Leyla Memış

Publication year - 2020

Publication title -

turkish journal of pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.305

H-Index - 14

eISSN - 1309-5730

pISSN - 1018-5615

DOI - 10.5146/tjpath.2020.01503

Subject(s) - adenocarcinoma , cancer research , lung cancer , medicine , adenocarcinoma of the lung , oncology , immunohistochemistry , pathology , epidermal growth factor receptor , cancer , biology

Patients with lung adenocarcinoma who harbor ALK gene rearrangements can demonstrate significant clinical benefit with ALK tyrosine kinase inhibitors. Insulin-like growth factor receptor 1 (IGFR1) is a cellular membrane receptor that is overexpressed in many tumors. It plays an important role in cancer progression and is associated with increased postoperative recurrence and poorer disease-free survival. The aim of this study was to determine the EML4-ALK mutation and IGFR1 expression in lung adenocarcinoma and analyze their prognostic value.

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